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In 1872, nearly 50 years before women were guaranteed the right to vote through the 19th Amendment, Susan B. Anthony was arrested and charged with casting an illegal ballot in that year's presidential election.
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In 1964, Patsy Mink became both the first Asian American woman and the first woman of color to be elected to Congress. She would later become the first Asian American to seek the Democratic presidential nomination.
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In 1849, Elizabeth Blackwell was the first U.S. woman to obtain a medical degree. She championed women in medicine (even opening a women's college) and urged preventative care and hygiene, noting male doctors didn't wash their hands between patients.
Although heavily involved in discovering parity violation, Chinese-American physicist Chien-Shiung Wu was overlooked when her male colleagues were given the 1957 Nobel Prize in Physics. Her work also included America's development of the atomic bomb.